Preprint / Version 1

Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells

Authors

  • Chia-Kai Lin aDepartment of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan
  • Bor-Yann Chen bDepartment of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan
  • Jasmine Ting cDepartment of Chemistry, College of Science, De La Salle University, Metro Manila 1004, Philippines
  • Kristian Rogio dSchool of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Metro Manila 1002, Philippines
  • Po-Wei Tsai eDepartment of Medical Science Industries, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan
  • Yung-Chuan Liu aDepartment of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan

Keywords:

Electron shuttles (ESs), Microbial fuel cells (MFCs), Houttuynia cordata, Bioenergy extraction, Quercitrin, Flavonoids

Abstract

Traditional herbal medicines usually contain electron shuttle (ES)-like structures compounds which are potential candidates for antiviral compounds selection. Houttuynia cordata is applied as a biomaterial to decipher its potential applications in bioenergy extraction in microbial fuel cells (MFCs) and anti-COVID-19 via molecular docking evaluation. Methods H. cordata leaves extracts by water and 60% ethanol solvent were analyzed for total polyphenols, antioxidant activity, cyclic voltammetry (CV), and MFCs. The bioactive compounds of H. cordata leaves extracts were assayed via LC/MS analysis. Identification of the marker substances for potential antiviral activity using a molecular docking model was provided. Significant findings 60% ethanol extract exhibits the highest total polyphenols and antioxidant activity compared with water extracts. Bioenergy extraction in MFCs showed that 60% ethanol extracts could give 1.76-fold more power generation compared to the blank. Flavonoids and their sugar-to-glycan ratios increased after CV scanning and they are expected to be effective ES substances. Quercitrin, from the H. cordata extract that shares an ES-like structure, was found to exhibit strong binding affinities towards ACE2 and RdRp. This indicated the potential of H. cordata leaves as a promising antiviral herb. Keywords: Electron shuttles (ESs), Microbial fuel cells (MFCs), Houttuynia cordata, Bioenergy extraction, Quercitrin, Flavonoids

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