Alcoholic Stem Extract of Coscinium fenestratum Regulates Carbohydrate Metabolism and Improves Antioxidant Status in Streptozotocin–Nicotinamide Induced Diabetic Rats
Authors
I Punitha
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576104, India
K Rajendran
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576104, India
Arun Shirwaikar
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal 576104, India
Annie Shirwaikar
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576104, India
Alcoholic extract of the stems of Coscinium fenestratum, a medicinal plant indigenous to India and Sri Lanka used in ayurveda and siddha medicine for treating diabetes, was studied for its carbohydrate metabolism effect and antioxidant status in streptozotocin–nicotinamide induced type 2 diabetic rats. Oral administration of C. fenestratum stem extract in graded doses caused a significant increase in enzymatic antioxidants such as catalase, superoxide dismutase, glutathione synthetase, peroxidase, and glutathione peroxidase and in the nonenzymatic antioxidants ascorbic acid, ceruloplasmin and tocopherol. Effects of alcoholic extract on glycolytic enzymes such as glucose-6-phosphate dehydrogenase, lactate dehydrogenase and hexokinase showed a significant increase in their levels, whereas a significant decrease was observed in the levels of gluconeogenic enzyme, glucose-6-phosphatase and alanine aminotransferase in treated diabetic rats. Serum creatinine and urea levels also declined significantly. This investigation demonstrates significant antidiabetic activity of C. fenestratum.
Keywords: carbohydrate metabolism, Coscinium fenestratum, enzymatic antioxidants, nonenzymatic antioxidants, streptozotocin–nicotinamide induced diabetes
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