Healing Properties of Some Indian Medicinal Plants against Indomethacin-Induced Gastric Ulceration of Rats
Authors
Sayanti Bhattacharya
Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences and IPGMERR, 244B, Acharya Jagadish Chandra Bose Road, Kolkata – 700 020, India
Susri Chaudhuri
Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences and IPGMERR, 244B, Acharya Jagadish Chandra Bose Road, Kolkata – 700 020, India
Subrata Chattopadhyay
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai – 400 085, India
Sandip Bandyopadhyay
Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences and IPGMERR, 244B, Acharya Jagadish Chandra Bose Road, Kolkata – 700 020, India
Keywords:
antioxidant, Indian medicinal plants, indomethacin, mucin, stomach ulcer
Abstract
The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol. Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents. The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities. The excellent healing activity of the extracts of P. betel and E. officinalis indicated a major role of mucin protection and regeneration in the healing of nonsteroidal anti-inflammatory drugs mediated stomach ulceration.
Keywords: antioxidant, Indian medicinal plants, indomethacin, mucin, stomach ulcer
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