Delivery of anti-inflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer
Authors
Hareesh Nair
aDepartment of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
Bokyung Sung
bCytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Vivek Yadav
bCytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Ramaswamy Kannappan
bCytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Madan Chaturvedi
bCytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Bharat Aggarwal
bCytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Extensive research within the last two decades has revealed that most chronic illnesses, including cancer, diabetes, and cardiovascular and pulmonary diseases, are mediated through chronic inflammation. Thus, suppressing chronic inflammation has the potential to delay, prevent, and even treat various chronic diseases, including cancer. Various nutraceuticals from fruits, vegetables, vitamins, spices, legumes, and traditional Chinese and Ayurvedic medicine have been shown to safely suppress proinflammatory pathways; however, their low bioavailability in vivo limits their use in preventing and treating cancer. We describe here the potential of nanotechnology to fill this gap. Several nutraceuticals, including curcumin, green tea polyphenols, coenzyme Q, quercetin, thymoquinone and others, have been packaged as nanoparticles and proven to be useful in “nano-chemoprevention” and “nano-chemotherapy.”
Keywords: Inflammation, diabetes, cancer, NF-κB, curcumin, nutraceuticals, nanotechnology
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