Antihyperglycemic activity of Tectona grandis Linn. bark extract on alloxan induced diabetes in rats
Authors
S Varma
Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha - 402 102, India
D Jaybhaye
Department of Pharmacology, Mahatma Gandhi Mission Hospital, Aurangabad - 431 001, Maharashtra, India
Keywords:
Alloxan, anti-hyperglycemic activity, bark extract, diabetes, Tectona grandis Linn
Abstract
Tectona Grandis Linn.(saag - tick wood), an indigenous medicinal plant, has a folk reputation among the Indian herbs as a hypoglycemic agent. The present study was carried out to evaluate the anti-hyperglycemic effect of T. grandis Linn. bark extract in control and alloxan-diabetic rats. Oral administration of the bark suspension of T. grandis (2.5 and 5 g/kg body wt.) for 30 days resulted in a significant reduction in blood glucose (from 250 ± 6.5 to 50 ± 2.5 mg/dL). Thus, the present study clearly shows that the T. grandis Linn. bark extract exerts anti-hyperglycemic activity.
Keywords: Alloxan, anti-hyperglycemic activity, bark extract, diabetes, Tectona grandis Linn
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