Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil
Authors
Feng Shi
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Ji-Hui Zhao
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Ying Liu
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Zhi Wang
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Yong-Tai Zhang
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Nian-Ping Feng
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Keywords:
solid lipid nanoparticles, frankincense oil, myrrh oil, evaporation release, antitumor activity, traditional Chinese medicine
Abstract
The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the oral delivery of frankincense and myrrh essential oils (FMO). Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE) were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM). The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 ± 3.6 nm, a ZP of −16.8 ± 0.4 mV, and an EE of 80.60% ± 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.
Keywords: solid lipid nanoparticles, frankincense oil, myrrh oil, evaporation release, antitumor activity, traditional Chinese medicine
Click on "Archives" to access the full archive of scientific preprints. You may use the categories and the search functionality to find select preprints you're interested in.
