Lipid-based ayurvedic formulations of a single herb-Yashtimadhu (Glycyrrhiza glabra): Pharmaceutical standardization, shelf-life estimation and comparative characterization
Authors
Sandeep Chavan
aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
Sushama Bhuvad
aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
Bhagyashri Kumbhalkar
aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
Tanhaji Walunj
aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
Vidya Gupta
aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
Vineeta Deshmukh
aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
Sukumar Sardeshmukh
aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
Sadanand Sardeshmukh
aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
Keywords:
Glycyrrhiza glabra, Ayurvedic lipid-based formulations, Ghee and oil, Licorice, Shelf-life, Stability study
Abstract
Single herb Ayurvedic lipid-based formulations of Glycyrrhiza glabra are used as oral, nasal and topical applications for reducing radiotherapy induced side effects in oral cavity cancer patients. These formulations are reported to be de-glycyrrhized, thus minimizing adverse effects of glycyrrhizin on longer consumption. Being a proprietary formulation with specific ratio of herb, lipid and liquid media, there is a need of pharmaceutical standardization and stability study to be conducted for quality control and quality assurance.
Objective
Standardization of Yashtimadhu Ghrut (YG) and Yashtimadhu Taila (YT) based on pharmaceutical characters, safety tests, chromatographic analysis and stability study.
Material and methods
Two formulations viz., YG and YT were prepared using cow's ghee and sesame oil, respectively. Basic physicochemical analysis, Thin Layer Chromatography, High Pressure Liquid Chromatography of glabridin and 18-β glycyrrhetinic acid, microbial load and heavy metal analysis were performed. Long term (0,3,6,9,12 months) as well as accelerated (0,3,6 months) stability study was conducted and extrapolated shelf-life was calculated for both the drugs.
Result
Organoleptic and basic physicochemical characters were comparable for both the products while safety parameters were within permissible limits. Extrapolated shelf-life was deduced as 1.74 and 0.67 years for YG and YT, respectively.
Conclusion
Single herb- G. glabra based lipid formulations were standardized and monographs were established. Shelf-life, though complying with classical Ayurvedic texts, indicates further research work with respect to pre-treatment of lipids and packaging systems for its enhancement.
Keywords: Glycyrrhiza glabra, Ayurvedic lipid-based formulations, Ghee and oil, Licorice, Shelf-life, Stability study
Author Biographies
Sandeep Chavan, aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
bAtharva Nature Healthcare Pvt Ltd, Pune, India
Tanhaji Walunj, aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
cMerieux Nutriscience Pvt Ltd, Navi Mumbai, India
Sukumar Sardeshmukh, aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
bAtharva Nature Healthcare Pvt Ltd, Pune, India
Sadanand Sardeshmukh, aBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Pune, India
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