Preprint / Version 1

Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats

Authors

  • Gaurav Kaithwas Department of Pharmaceutical Sciences, Assam University, Silchar-788 011, Assam, India
  • Raju Gautam Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali- 160 062, Punjab, India.
  • Sanjay Jachak Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali- 160 062, Punjab, India.
  • Arvind Saklani Department of Natural Products, 1-Nirlon Complex, Piramal Life Sciences, Goregaon, Mumbai- 400 063

Keywords:

Ajuga bracteosa, Adjuvant, Formaldehyde, Turpentine, Cyclooxygenase

Abstract

Objective To evaluate the antiarthritic activity of Ajuga bracteosa using albino rats. Methods The antiarthritic activity of 70% ethanolic extract of Ajuga bracteosa (EEAB) was evaluated against turpentine oil- and formaldehyde- induced acute non immunological and complete freund's adjuvant (CFA)-induced chronic immunological arthritis in albino rats. Results EEAB showed a significant (P<0.05) and dose dependent inhibitory effect against acute and chronic models of arthritis. EEAB exhibited better antiarthritic activity than the standard aspirin. Conclusions EEAB exhibits a significant and promising antiarthritic activity against acute and chronic arthritis and supports the traditional use of Ajuga bracteosa for rheumatism and other inflammatory diseases. Keywords: Ajuga bracteosa, Adjuvant, Formaldehyde, Turpentine, Cyclooxygenase

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