The development of Terminalia chebula Retz. (Combretaceae) in clinical research
Authors
Anwesa Bag
Agricultural and Ecological Research Unit, Indian Statistical Institute 203, Barrackpore Trunk Road Kolkata-700 108, India
Subir Bhattacharyya
Agricultural and Ecological Research Unit, Indian Statistical Institute 203, Barrackpore Trunk Road Kolkata-700 108, India
Rabi Chattopadhyay
Agricultural and Ecological Research Unit, Indian Statistical Institute 203, Barrackpore Trunk Road Kolkata-700 108, India
Keywords:
Terminalia chebula, Human diseases, Medicinal value, Bioactive constituents, Safety evaluation
Abstract
Medicinal plants are part and parcel of human society to combat diseases from the dawn of civilization. Terminalia chebula Retz. (Fam. Combretaceae), is called the ‘King of Medicine’ in Tibet and is always listed at the top of the list of ‘Ayurvedic Materia Medica’ because of its extraordinary power of healing. The whole plant possesses high medicinal value and traditionally used for the treatment of various ailments for human beings. Some of the folklore people used this plant in the treatment of asthma, sore throat, vomiting, hiccough, diarrhea, dysentery, bleeding piles, ulcers, gout, heart and bladder diseases. The plant has been demonstrated to possess multiple pharmacological and medicinal activities, such as antioxidant, antimicrobial, antidiabetic, hepatoprotective, anti-inflammatory, antimutagenic, antiproliferative, radioprotective, cardioprotective, antiarthritic, anticaries, gastrointestinal motility and wound healing activity. But no systematic updated information on the therapeutic effectiveness of Terminalia chebula, a popular herbal remedy in India and South-East Asia has so far been reported. This review highlights an updated information particularly on the phytochemistry and various pharmacological and medicinal properties of Terminalia chebula Retz. and some of its isolated compounds, along with their safety evaluation. This may provide incentive for proper evaluation of the plant as medicinal agent against the human diseases and also to bridge the lacunae in the existing literature and future scope which may offer immense opportunity for researchers engaged in validation of the traditional claims and development of safe and effective botanical medicine.
Keywords: Terminalia chebula, Human diseases, Medicinal value, Bioactive constituents, Safety evaluation
Author Biographies
Anwesa Bag, Agricultural and Ecological Research Unit, Indian Statistical Institute 203, Barrackpore Trunk Road Kolkata-700 108, India
Chemistry (Forensic Analysis) Programme Faculty of Applied Sciences, Universiti Teknologi MARA 40450 Shah Alam, Selangor, Malaysia. Tel: +603-55437855 Fax: +603-55444562 E-mail: [email protected]
Subir Bhattacharyya, Agricultural and Ecological Research Unit, Indian Statistical Institute 203, Barrackpore Trunk Road Kolkata-700 108, India
Chemistry (Forensic Analysis) Programme Faculty of Applied Sciences, Universiti Teknologi MARA 40450 Shah Alam, Selangor, Malaysia. Tel: +603-55437855 Fax: +603-55444562 E-mail: [email protected]
Rabi Chattopadhyay, Agricultural and Ecological Research Unit, Indian Statistical Institute 203, Barrackpore Trunk Road Kolkata-700 108, India
Chemistry (Forensic Analysis) Programme Faculty of Applied Sciences, Universiti Teknologi MARA 40450 Shah Alam, Selangor, Malaysia. Tel: +603-55437855 Fax: +603-55444562 E-mail: [email protected]
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