A comparative evaluation of intestinal transit time of two dosage forms of Haritaki [Terminalia chebula Retz.]
Authors
Yogesh Jirankalgikar
Ph.D. Scholar, Department of Basic Principles, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
B Ashok
Research Associate, Drug Discovery Group, Research and Development, Himalaya Health Care, Bengaluru, Karnataka, India
Rambabu Dwivedi
Professor and Head, Department of Basic Principles, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
Haritaki is praised as the best salutary drug which can be used in almost all ages of human life and is reputed for its Anulomana property. In Ayurveda, it has been mentioned that fruits of Haritaki when used in different forms give different type of actions. As the prime therapeutic utility of Haritaki is Anulomana, in the present study, two dosage forms of Haritaki fruits namely Churna and Vati were evaluated for intestinal transit time to evaluate its effect in two different dosage forms. Mature fruits were collected, authenticated, and processed as per classics to get Churna and Vati. Test drugs were administered in the dose of 550 mg/kg and evaluation on intestinal transit time was carried out by adopting kaolin expulsion test in mice. The results show that both the dosage forms of Haritaki significantly shortened intestinal transit time and between them Churna form is found to be better.
Keywords: Anulomana, Churna, Haritaki, intestinal transit, kaolin, Terminalia Chebula, Vati
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