Hypoglycemic and anti-hyperglycemic activity of Guduchi Satva in experimental animals
Authors
Rohit Sharma
Ph.D. Scholar, Department of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar, Gujarat, India
Vijay Kumar
Assistant Professor, Department of Pharmacology, Gurukul College of Pharmacy, Suratgarh, Rajasthan, India
B Ashok
Discovery Scientist, Research and Development, The Himalaya Healthcare, Makali, Bangalore, Karnataka, India
R Galib
Assistant Professor, Department of Rasashastra and Bhaishajya Kalpana, Including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
Pradeep Prajapati
Professor and Head, Department of Rasashastra and Bhaishajya Kalpana, Including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
B Ravishankar
Director, Research and Development, SDM Research Centre for Ayurveda and Allied Sciences, Udupi, Karnataka, India
Keywords:
Guduchi Satva, anti-hyperglycemic, hypoglycemic
Abstract
Over the centuries, herbs have served as a major source of medicines for prevention and treatment of diseases including diabetes mellitus. These herbs are getting more importance around the globe and many studies have provided safety and efficacy of such herbal drugs in different condition. Guduchi (Tinospora cordifolia [Willd.] Miers) is reported as highly potent Pramehahara (anti-diabetic) herb in Ayurveda and Guduchi Satva (GS) is popularly used to treat Paittika type of Prameha. In the present study, GS prepared from the stem of T. cordifolia was evaluated for hypoglycemic and anti-hyperglycemic activity in 18 h fasted mice. GS was suspended in distilled water and administered to animals at the dose of 130 mg/kg that showed the marginal reduction in blood sugar level (BSL) at all the time intervals in normoglycemic mice. In anti-hyperglycemic activity, administration of GS prior to glucose over load failed to attenuate BSL at all-time interval in comparison to glucose control group. The study concludes that mild hypoglycemic insignificant anti-hyperglycemic activities of GS.
Keywords: Guduchi Satva, anti-hyperglycemic, hypoglycemic
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