SLDV Kadali
Tutor, Department of Pharmacology, NRI Medical College, A.P, India.
Das MC
Professor and HOD, Department of Pharmacology, NRI Medical College, A.P, India.
Srinivasa ASR
Assosiate Professor, Department of Pharmacology, NRI Medical College, A.P, India.
Karuna G
Tutor, Department of Pharmacology, NRI Medical College, A.P, India.
Keywords:
Brahmi, Antidepressant activity, Forced swim test, Tail suspension test
Abstract
Context: In traditional system of medicine brahmi has been used to enhance memory. Recently it has been reported to have action in psychiatric disorders. With these backgrounds the work has been undertaken to study antidepressant activity of brahmi in albino mice.
Aim: To evaluate antidepressant activity of brahmi in experimental models.
Materials and Methods: The antidepressant activity was studied in albino mice using forced swimming test (FST), tail suspension test (TST) and shock induced depression (SID). Imipramine (10mg/kg), fluoxetine (30mg/kg) were used as standard drugs and brahmi (10, 20, 30mg/kg) was used as test drug.
Results: Brahmi exhibited significant decrease in duration of immobility in FST and reduced the shock induced decrease in activity in SID models. It didn’t show any activity in the TST model.
Conclusion: Brahmi has shown antidepressant activity in FST and SID.
Keywords: Brahmi, Antidepressant activity, Forced swim test, Tail suspension test
Click on "Archives" to access the full archive of scientific preprints. You may use the categories and the search functionality to find select preprints you're interested in.
