Traditional Chinese and Indian medicine in the treatment of opioid-dependence: a review
Authors
Fatemeh Doosti
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Saeedeh Dashti
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Seyed Tabatabai
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Hossein Hosseinzadeh
Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Keywords:
Key Words: Addiction, Opioid Tolerance, Opioid Withdrawal, Traditional Chinese Medicine, Traditional Indian Medicine
Abstract
Objective: In this study, the current literatures on the use of herbs and herbal preparations of Traditional Chinese and Indian Medicine for the treatment of opioid addiction were reviewed.
Matherials and Methods: Search was done in databases such as Pub Med, Science Direct, Scopus, Springer Link, and Google Scholar.
Results: Among 18 retrieved studies, 3 studies were about asafetida extract, an approved preparation for ameliorating drug abstinence in China. Chinese preparations including Composite Dong Yuan Gao, Qingjunyin and TJ-97 (a water extract of dai-bofu-to) as well as Indian ones, Mentate and Shilajit, were reported to have positive effects against opioid withdrawal, dependence, and tolerance. Moreover, Levo-tetrahydropalmatine and L-Stepholidine, in addition to extracts of Caulis Sinomenii and Sinomenium acutum showed similar effects.
Banxia Houpu Decoction, Fu-Yuan pellet, Jinniu capsules, Qingjunyin, Tai-Kang-Ning capsule, and Xuan Xia Qudu Jiaonang (WeiniCom) from Chinese preparations, showed anti-addiction effects in randomized, double-blind and, in some studies, multicenter clinical trials.
Conclusion : Traditional herbal preparations of China and India have anti-addiction effects with less adverse effects than alpha2-adrenergic or opioid agonists.
Key Words: Addiction, Opioid Tolerance, Opioid Withdrawal, Traditional Chinese Medicine, Traditional Indian Medicine
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