Preprint / Version 1

Atypical Antidepressant Activity of 3,4-Bis(3,4-Dimethoxyphenyl) Furan-2,5-Dione Isolated from Heart Wood of Cedrus deodara, in Rodents

Authors

  • Nitesh Kumar Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
  • Daniel Dhayabaran Farooqia College of Pharmacy, Mysore 570021, Karnataka, India.
  • Madhavan Nampoothiri Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
  • Krishnadas Nandakumar Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
  • A Puratchikody Department of Pharmaceutical Technology, Anna University Chennai, Regional Office, Tiruchirappalli 620 024, Tamil Nadu, India.
  • Natasha Lalani Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
  • Karima Dawood Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
  • Aanesha Ghosh Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.

Keywords:

Anti-depressant, Cedrus, Noradrenaline, Serotonin

Abstract

Cedrus deodara (Pinaceae) has been used traditionally in Ayurveda for the treatment of central nervous system disorders. 3,4-bis(3,4-dimethoxyphenyl)furan-2,5-dione (BDFD) was isolated from heart wood of Cedrus deodara and was shown to have antiepileptic and anxiolytic activity. Thus, the present study was aimed to explore its anti-depressant effect and to correlate the effect with serotonin and nor adrenaline levels of brain. Albino mice were used as experimental animal. Animals were divided in to three groups; vehicle control, imipramine (30 mg/kg i.p.), BDFD (100 mg/kg i.p.). Tail suspension test (TST) and forced swim test (FST) was performed to evaluate antidepressant effect of BDFD. BDFD (100 mg/kg, i.p.) showed a significant decrease in immobility time when subjected to FST whereas immobility time was not significantly altered in TST. BDFD treatment increased serotonin and noradrenaline levels in the brain which is indicative of BDFD having possible atypical antidepressant action. Keywords: Anti-depressant, Cedrus, Noradrenaline, Serotonin

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