Effect of Neem oil and Haridra on non-healing wounds
Authors
Anjali Singh
Department of Dravyaguna, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Anil Singh
Department of Dravyaguna, Banaras Hindu University, Varanasi, Uttar Pradesh, India
G Narayan
Department of Human and Molecular Genetics, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Teja Singh
Department of Community Medicine, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Vijay Shukla
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Keywords:
Chronic wound, Haridra, microscopic angiogenesis grading system score, Neem oil, wound healing
Abstract
In Ayurveda, Vrana (wound) has stated as tissue destruction and discoloration of viable tissue due to various etiology. In Sushruta Samhita, Sushruta described Vrana as a main subject. Most commonly Vrana can be classified into Shuddha and Dushta Vrana (chronic wound/nonhealing ulcers). Among the various drugs mentioned for Dushta Vrana, two of them, Neem (Azadirechta indica A. Juss) oil and Haridra (Curcuma longa Linn.) powder are selected for their wide spectrum action on wound.
Aim:
To compare the effect of Neem oil and Haridra in the treatment of chronic non-healing wounds.
Materials and Methods:
Total 60 patients of wounds with more than 6 weeks duration were enrolled and alternatively allocated to Group I (topical application of Neem oil), Group II (Haridra powder capsules, 1 g 3 times orally) and Group III (both drugs). Duration of treatment was considered until complete healing of the wound, whereas 4th and 8th week were considered for assessment of 50% healing. Wound size was measured and recorded at weekly intervals. Wound biopsy was repeated after 4 weeks for assessment of angiogenesis and deoxyribonucleic acid (DNA) analysis.
Results:
After 8 weeks of treatment, 50% wound healing was observed in 43.80% patients of Group I, 18.20% patients of Group II, and 70.00% patients of Group III. Microscopic angiogenesis grading system scores and DNA concentration showed highly significant effect of combined use of both drugs when compared before and after results of treatment (P < 0.001).
Conclusion:
Topical use of Neem oil and oral use of Haridra powder capsule used in combination were found effective for chronic non-healing wounds.
Keywords: Chronic wound, Haridra, microscopic angiogenesis grading system score, Neem oil, wound healing
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