Preprint / Version 1

Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice

Authors

  • Nora Gray Department of Neurology, Oregon Health and Science University, Portland, OR, USA 97239
  • Christopher Harris Department of Neurology, Oregon Health and Science University, Portland, OR, USA 97239
  • Joseph Quinn Department of Neurology, Oregon Health and Science University, Portland, OR, USA 97239
  • Amala Soumyanath Department of Neurology, Oregon Health and Science University, Portland, OR, USA 97239

Keywords:

Aging, cognition, Centella asiatica, mitochondrial dysfunction, reactive oxygen species

Abstract

Ethnopharmacological relevance This study investigates the cognitive enhancing effects of the plant Centella asiatica which is widely used Ayurvedic and traditional Chinese medicine. Aim of the study The goal of this study was to determine the effects of a water extract of the medicinal plant Centella asiatica (CAW) on cognitive ability as well as mitochondrial and antioxidant response pathways in vivo. Materials and methods Old and young C57BL/6 mice were treated with CAW (2mg/mL) in their drinking water. Learning and memory was assessed using Morris Water Maze (MWM) and then tissue was collected and gene expression analyzed. Results CAW improved performance in the MWM in aged animals and had a modest effect on the performance of young animals. CAW also increased the expression of mitochondrial and antioxidant response genes in the brain and liver of both young and old animals. Expression of synaptic markers was also increased in the hippocampus and frontal cortex, but not in the cerebellum of CAW-treated animals. Conclusions These data indicate a cognitive enhancing effect of CAW in healthy mice. The gene expression changes caused by CAW suggest a possible effect on mitochondrial biogenesis, which in conjunction with activation of antioxidant response genes could contribute to cognitive improvement. Keywords: Aging, cognition, Centella asiatica, mitochondrial dysfunction, reactive oxygen species

Author Biography

Joseph Quinn, Department of Neurology, Oregon Health and Science University, Portland, OR, USA 97239

Department of Neurology and Parkinson’s Disease Research Education and Clinical Care Center (PADRECC), Portland Veterans Affairs Medical Center, Portland, OR, USA 97239

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