High therapeutic potential of Spilanthes acmella: A review
Authors
Veda Prachayasittikul
Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
Supaluk Prachayasittikul
Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology,Mahidol University, Bangkok 10700, Thailand
Somsak Ruchirawat
Laboratory of Medicinal Chemistry, Chulabhorn Research Institute and ChulabhornGraduate Institute, Bangkok 10210, Thailand
Virapong Prachayasittikul
Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
Keywords:
Spilanthes acmella, bioactive metabolites, bioactivities, structure-activity relationships, in vitro production
Abstract
Spilanthes acmella, a well known antitoothache plant with high medicinal usages, has been recognized as an important medicinal plant and has an increasingly high demand worldwide. From its traditional uses in health care and food, extensive phytochemical studies have been reported. This review provides an overview and general description of the plant species, bioactive metabolites and important pharmacological activities including the preparation, purification and in vitro large-scale production. Structure-activity relationships of the bioactive compounds have been discussed. Considering data from the literature, it could be demonstrated that S. acmella possesses diverse bioactive properties and immense utilization in medicine, health care, cosmetics and as health supplements. As a health food, it is enriched with high therapeutic value with high potential for further development.
Keywords: Spilanthes acmella, bioactive metabolites, bioactivities, structure-activity relationships, in vitro production
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