Anti-diarrheal and anti-inflammatory activities of aqueous extract of the aerial part of Rubia cordifolia
Authors
Xue-Peng Gong
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Hangkong Road, Wuhan, 430030 People’s Republic of China
Yuan-Yuan Sun
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Hangkong Road, Wuhan, 430030 People’s Republic of China
Wei Chen
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Hangkong Road, Wuhan, 430030 People’s Republic of China
Xia Guo
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Hangkong Road, Wuhan, 430030 People’s Republic of China
Jian-Kun Guan
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Hangkong Road, Wuhan, 430030 People’s Republic of China
Dong-Yan Li
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Hangkong Road, Wuhan, 430030 People’s Republic of China
Guang Du
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Hangkong Road, Wuhan, 430030 People’s Republic of China
In Shaanxi province, China, the aqueous extract of Rubia cordifolia’s aerial part (AERCAP) is traditionally used to manage diarrhea. However, there is no scientific evidence to verify the safety and efficacy of its use. The aim of this study was to investigate the anti-diarrheal and anti-inflammatory effects of AERCAP by using a rodent model.
Methods
The anti-diarrheal effects were studied by senna leaf-induced diarrheal and intestinal transit experiments in mice. The anti-inflammatory activity was investigated by trinitrobenzenesulfonic acid (TNBS)-induced colonic inflammation in rats.
Results
The results indicated that AERCAP delayed the onset of semi-solid feces, reduced the evacuation index (EI) in senna leaf-induced diarrheal in mice, and inhibited the propulsive movement in castor oil-induced intestinal transit but not in the normal intestinal transit test. The results were compared with the standard anti-diarrheal drug loperamide. Additionally, oral treatment with AERCAP significantly decreased the macroscopic damage area, improved the microscopic structure, and reduced the malondialdehyde (MDA) content, IL-1β and TNF-α levels in colonic tissue compared with the TNBS control group in rats.
Conclusions
AERCAP exhibited anti-diarrheal and anti-inflammatory activities in a rodent model. The study validated the traditional use of the plant in Chinese herbal medicine as a valuable natural remedy for the treatment of diarrhea.
Keyword: Anti-diarrheal, Anti-inflammatory, Rubia cordifolia Aerial part, Aqueous extract, Rodent model
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