Rasayana effect of Guduchi Churna on the life span of Drosophila melanogaster
Authors
Pankaj Pathak
Department of Basic Principles, JSS Ayurveda Medical College, Mysore, Karnataka, India
Mahesh Vyas
Department of Basic Principles, Institute for Postgraduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
Hitesh Vyas
Department of Basic Principles, Institute for Postgraduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
Mukesh Naria
Department of Pharmacology Laboratory, Institute for Postgraduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
Introduction:
The Drosophila melanogaster is one of the most extensively studied animal models for understanding the process of aging and longevity. This fly is being used for genetic studies since almost a century. Guduchi (Tinospora cordifolia [Wild.] Miers.) is an Ayurvedic drug used as Rasayana (rejuvenation) due to its antiaging effect.
Aim:
To explore the potential of Guduchi Churna (powder of T. cordifolia) on the life span of D. melanogaster using adult feeding method.
Materials and Methods:
For experimental setups, the regular food media were mixed with Guduchi Churna in different concentrations (0.25 g/100 ml, 0.50 g/100 ml, and 0.70 g/100 ml). Flies were exposed to these concentrations for 30 days.
Results:
Increase in the lifespan was observed in both parent and F-1 generation. Applying of ANOVA revealed significant difference between control and drug groups. The longevity effect, in the drug group was seen even on F-1 generation.
Conclusion:
Guduchi Churna enhances the life span of D. melanogaster in both parent and F-1 generation.
Keywords: Drosophila melanogaster, Guduchi Churna, longevity, Rasayana, Tinospora cordifolia
Click on "Archives" to access the full archive of scientific preprints. You may use the categories and the search functionality to find select preprints you're interested in.
