Cichorium intybus L. (Asteraceae family) is a worldwide grown plant known as chicory. In traditional medicine, this plant is used as diuretic, anti-inflammatory, digestive, cardiotonic and liver tonic. Chromatographic purification of the supercritical fluid extract of aerial parts of C. intybus on silica gel column led to isolation of three compounds: new compound, 28β-hydroxytaraxasterol (I), and two known compounds usnic acid (II), and β-sitosterol (III). Purification of the ethanolic extract of aerial parts of this plant on silica gel column chromatography yielded four compounds: 1,3-dioleylglycerate (IV), sitoindoside II (V), 11β-13-dihydrolactucin (VI), and β-sitosterol-3-O-glucoside (VII). The structures of the isolated compounds were determined by their 1D, 2D NMR and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding, as well as antibacterial, antifungal, and antimalarial activities. Compound I showed moderate activity (60.5 % displacement) towards CB1 receptor.
Keywords: Cichorium intybus, isolation, cannabinoid receptor, opioid receptor
Author Biographies
Dinara Satmbekova, aDepartment of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty 050000, Republic of Kazakhstan
bNational Center for Natural Product Research, University of Mississippi, University, 38677, USA
Yerkebulan Orazbekov, aDepartment of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty 050000, Republic of Kazakhstan
bNational Center for Natural Product Research, University of Mississippi, University, 38677, USA
Samir Ross, bNational Center for Natural Product Research, University of Mississippi, University, 38677, USA
cDepartmant of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
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