Preprint / Version 1

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

Authors

  • Mehdi Sharifi-Rad Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran; [email protected]
  • Marcello Iriti Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, Milan 20133, Italy
  • Natália Martins Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal
  • Bahare Salehi Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran
  • Jovana Rajkovic Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade 11129, Serbia; [email protected]
  • Adedayo Ademiluyi Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria; [email protected]
  • Miquel Martorell Nutrition and Dietetics Department, School of Pharmacy, University of Concepción, Concepción 4070386, VIII–Bio Bio Region, Chile; [email protected]
  • Farukh Sharopov Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan; [email protected]
  • Patrick Fokou Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde Po.Box 812, Cameroon; [email protected]
  • Javad Sharifi-Rad Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran

Keywords:

peptic ulcer, Helicobacter pylori, gastric cancer, bioactive phytochemicals, herbal remedies, traditional healing systems

Abstract

In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed. Keywords: peptic ulcer, Helicobacter pylori, gastric cancer, bioactive phytochemicals, herbal remedies, traditional healing systems

Author Biographies

Natália Martins, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal

Institute for Research and Innovation in Health (i3S), University of Porto–Portugal, Porto 4200-135, Portugal

Bahare Salehi, Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran

Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran

Javad Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran

Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada

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