Preprint / Version 1

Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders

Authors

  • Maria Neag Department of Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Andrei Mocan Department of Pharmaceutical Botany, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Javier Echeverría Department of Environmental Sciences, Universidad de Santiago de Chile, Santiago de Chile, Chile
  • Raluca Pop Department of Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Corina Bocsan Department of Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Gianina Crişan Department of Pharmaceutical Botany, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Anca Buzoianu Department of Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania

Keywords:

berberine, botanical occurrence, traditional uses, extraction methods, biological activities

Abstract

Berberine-containing plants have been traditionally used in different parts of the world for the treatment of inflammatory disorders, skin diseases, wound healing, reducing fevers, affections of eyes, treatment of tumors, digestive and respiratory diseases, and microbial pathologies. The physico-chemical properties of berberine contribute to the high diversity of extraction and detection methods. Considering its particularities this review describes various methods mentioned in the literature so far with reference to the most important factors influencing berberine extraction. Further, the common separation and detection methods like thin layer chromatography, high performance liquid chromatography, and mass spectrometry are discussed in order to give a complex overview of the existing methods. Additionally, many clinical and experimental studies suggest that berberine has several pharmacological properties, such as immunomodulatory, antioxidative, cardioprotective, hepatoprotective, and renoprotective effects. This review summarizes the main information about botanical occurrence, traditional uses, extraction methods, and pharmacological effects of berberine and berberine-containing plants. Keywords: berberine, botanical occurrence, traditional uses, extraction methods, biological activities

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