Preprint / Version 1

Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins

Authors

  • Kendall Byler Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected]
  • William Setzer Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected]

Keywords:

frankincense, Boswellia, cembranoids, cneorubenoids, boswellic acids, molecular docking

Abstract

Background: Frankincense, the oleo-gum resin of Boswellia trees, has been used in traditional medicine since ancient times. Frankincense has been used to treat wounds and skin infections, inflammatory diseases, dementia, and various other conditions. However, in many cases, the biomolecular targets for frankincense components are not well established. Methods: In this work, we have carried out a reverse docking study of Boswellia diterpenoids and triterpenoids with a library of 16034 potential druggable target proteins. Results: Boswellia diterpenoids showed selective docking to acetylcholinesterase, several bacterial target proteins, and HIV-1 reverse transcriptase. Boswellia triterpenoids targeted the cancer-relevant proteins (poly(ADP-ribose) polymerase-1, tankyrase, and folate receptor β), inflammation-relevant proteins (phospholipase A2, epoxide hydrolase, and fibroblast collagenase), and the diabetes target 11β-hydroxysteroid dehydrogenase. Conclusions: The preferential docking of Boswellia terpenoids is consistent with the traditional uses and the established biological activities of frankincense. Keywords: frankincense, Boswellia, cembranoids, cneorubenoids, boswellic acids, molecular docking

Author Biography

William Setzer, Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected]

Aromatic Plant Research Center, 230 N 1200 E, Suite 102, Lehi, UT 84043, USA

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