Association of genetic polymorphism of interleukin-17A & interleukin-17F with susceptibility of psoriasis
Authors
Rajinder Kaur
Department of Human Genetics, Punjabi University, Patiala, India
Arun Rawat
Department of Human Genetics, Punjabi University, Patiala, India
Sunil Kumar
Department of Human Genetics, Punjabi University, Patiala, India
Wani Aadil
Department of Human Genetics, Punjabi University, Patiala, India
Tahseena Akhtar
Department of Human Genetics, Punjabi University, Patiala, India
Tarun Narang
Department of Dermatology, Post Graduate Institute of Medical Education & Research, Chandigarh, India
Dimple Chopra
Department of Dermatology, Government Rajindra Medical College & Hospital, Patiala, India
Keywords:
Cytokine, gene polymorphism, interleukins, psoriasis, single nucleotide polymorphism
Abstract
Background & objectives:
Psoriasis is a chronic inflammatory skin disease with unknown aetiology. So far studies have confirmed that interleukins, pro-inflammatory factors and T-cell activation play major role in the development of disease. Interleukin-17 (IL-17) a T helper inflammatory cytokine, was found to be positively correlated with severity of psoriasis. However, the specific mechanism has not been clarified. IL-17A and IL-17F are group members of IL17 family cytokines and found to be located adjacent to one another on the same human chromosome, 6p12. The present study was designed to identify the association between IL-17A and IL-17F gene polymorphism with susceptibility of psoriasis in north Indian population.
Methods:
A total of 166 psoriasis patients and 150 healthy controls were genotyped for IL-17A and IL-17F gene polymorphism by amplification refractory mutation system-polymerase chain reaction method. One single nucleotide polymorphism (SNP) was analysed in IL-17A (rs10484879) and one SNP in IL-17F (rs763780) to look for an association with psoriasis.
Results:
Our study indicated decreased frequency of IL-17A (rs10484879) G allele (51.8 vs. 65.0%), and IL-17F (rs763780) C allele (36.5 vs. 45.7%) in psoriatic patients as compared to healthy controls.
Interpretation & conclusions:
The present findings suggest that IL-17A (rs10484879) G/T and IL-17F (rs763780) C/T gene polymorphisms may contribute in pathogenesis of psoriasis. Further studies need to be done to confirm these findings.
Keywords: Cytokine, gene polymorphism, interleukins, psoriasis, single nucleotide polymorphism
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