Preprint / Version 1

Facile fabrication of Nishamalaki churna mediated silver nanoparticles with antibacterial application

Authors

  • Bhavna Ghosh aSchool of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India
  • Anindya Bose aSchool of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India
  • Ankita Parmanik aSchool of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India
  • Sanjay Ch cDepartment of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus. Jawahar Nagar, Kapra Mandal. Medchal District, Telangana, 500 078, India
  • Milan Paul cDepartment of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus. Jawahar Nagar, Kapra Mandal. Medchal District, Telangana, 500 078, India
  • Swati Biswas cDepartment of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus. Jawahar Nagar, Kapra Mandal. Medchal District, Telangana, 500 078, India
  • Goutam Rath aSchool of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India
  • Debapriya Bhattacharya dCenter for Biotechnology, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India

Keywords:

Antimicrobial resistance, Biofilm, Green synthesis, Ayurvedic formulation, Amlaki, Turmeric

Abstract

Antimicrobial resistance (AMR) is one of the most serious threats to today's healthcare system. The prime factor behind increasing AMR is the formation of complex bacterial biofilms which acts as the protective shield between the bacterial cell and the antimicrobial drugs. Among various nanoformulations, green synthesized metallic silver nanoparticles are currently gaining research focus in safely breaking bacterial biofilms due to the inherent antimicrobial property of silver. In the current work, the aqueous extract of the ayurvedic formulation Nishamalaki churna is used to exhibit one pot green synthesis of silver nanoparticles. The physicochemical characteristics of Nishamalaki churna extract mediated AgNPs were evaluated using various analytical techniques, like UV–Visible spectrophotometer, FT-IR spectroscopy, SEM, XRD, DLS-Zeta potential analyzer etc. The synthesized spherical AgNPs were well formed within the size range of 30 nm to 80 nm. Furthermore, the synthesized AgNPs showed potent antibacterial effects against two primary AMR-causing bacterial species like Staphylococcus aureus and Pseudomonas aeruginosa with the successful destruction of their biofilm formation. Additionally, these AgNPs have shown profound antioxidant and anti-inflammatory activities as desirable add-on effects required by a prospective antibacterial agent. Keywords: Antimicrobial resistance, Biofilm, Green synthesis, Ayurvedic formulation, Amlaki, Turmeric

Author Biography

Bhavna Ghosh, aSchool of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India

bSri Jayadev College of Pharmaceutical Sciences, Naharkanta, Via: Balianta, Bhubaneswar, Odisha, 752101, India

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