Preprint / Version 1

Plant Extracts and Reactive Oxygen Species as Two Counteracting Agents with Anti- and Pro-Obesity Properties

Authors

  • Hanna Zielinska-Blizniewska Department of Allergology and Respiratory Rehabilitation, Medical University of Lodz, 90-725 Lodz, Poland; [email protected] (H.Z.-B.); [email protected] (K.M.)
  • Przemyslaw Sitarek Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland; [email protected]
  • Anna Merecz-Sadowska Department of Economic Informatics, University of Lodz, 90-214 Lodz, Poland; [email protected] (M.J.); [email protected] (R.Z.)
  • Katarzyna Malinowska Department of Allergology and Respiratory Rehabilitation, Medical University of Lodz, 90-725 Lodz, Poland; [email protected] (H.Z.-B.); [email protected] (K.M.)
  • Karolina Zajdel Department of Medical Informatics and Statistics, Medical University of Lodz, 90-645 Lodz, Poland; [email protected]
  • Marta Jablonska Department of Economic Informatics, University of Lodz, 90-214 Lodz, Poland; [email protected] (M.J.); [email protected] (R.Z.)
  • Tomasz Sliwinski Laboratory of Medical Genetics, Faculty of Environmental Protection, University of Lodz, 90-236 Lodz, Poland; [email protected]
  • Radoslaw Zajdel Department of Economic Informatics, University of Lodz, 90-214 Lodz, Poland; [email protected] (M.J.); [email protected] (R.Z.)

Keywords:

obesity, plant extracts, polyphenols, reactive oxygen species

Abstract

Obesity is a complex disease of great public health significance worldwide: It entails several complications including diabetes mellitus type 2, cardiovascular dysfunction and hypertension, and its prevalence is increasing around the world. The pathogenesis of obesity is closely related to reactive oxygen species. The role of reactive oxygen species as regulatory factors in mitochondrial activity in obese subjects, molecules taking part in inflammation processes linked to excessive size and number of adipocytes, and as agents governing the energy balance in hypothalamus neurons has been examined. Phytotherapy is the traditional form of treating health problems using plant-derived medications. Some plant extracts are known to act as anti-obesity agents and have been screened in in vitro models based on the inhibition of lipid accumulation in 3T3-L1 cells and activity of pancreatic lipase methods and in in vivo high-fat diet-induced obesity rat/mouse models and human models. Plant products may be a good natural alternative for weight management and a source of numerous biologically-active chemicals, including antioxidant polyphenols that can counteract the oxidative stress associated with obesity. This review presents polyphenols as natural complementary therapy, and a good nutritional strategy, for treating obesity without serious side effects. Keywords: obesity, plant extracts, polyphenols, reactive oxygen species

Author Biography

Katarzyna Malinowska, Department of Allergology and Respiratory Rehabilitation, Medical University of Lodz, 90-725 Lodz, Poland; [email protected] (H.Z.-B.); [email protected] (K.M.)

Department of Economic Informatics, University of Lodz, 90-214 Lodz, Poland; [email protected] (M.J.); [email protected] (R.Z.)

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