Preprint / Version 1

Treatment of lead and arsenic poisoning in anuric patients – a case report and narrative review of the literature

Authors

  • Chun-Yuan Hsiao Department of Renal Medicine, Middlemore Hospital, Counties Manukau Health, Private Bag 93311, Otahuhu, Auckland, 1640 New Zealand
  • Chip Gresham Department of Emergency Medicine, Middlemore Hospital, Auckland, 1640 New Zealand
  • Mark Marshall Department of Renal Medicine, Middlemore Hospital, Counties Manukau Health, Private Bag 93311, Otahuhu, Auckland, 1640 New Zealand

Keywords:

Arsenic poisoning, Lead poisoning, Chelators, Anuria, Extracorporeal blood purification

Abstract

Heavy metal poisoning can cause debilitating illness if left untreated, and its management in anuric patients poses challenges. Literature with which to guide clinical practice in this area is rather scattered. Case presentation We present a case of symptomatic lead and arsenic poisoning from use of Ayurvedic medicine in a 28-year-old man with end-stage kidney disease on chronic hemodialysis. We describe his treatment course with chelating agents and extracorporeal blood purification, and review the relevant literature to provide general guidance. Conclusion Cumulative clinical experience assists in identifying preferred chelators and modalities of extracorporeal blood purification when managing such patients. However, a larger body of real-world or clinical trial evidence is necessary to inform evidence-based guidelines for the management of heavy metal poisoning in anuric patients. Keywords: Arsenic poisoning, Lead poisoning, Chelators, Anuria, Extracorporeal blood purification

Author Biographies

Chip Gresham, Department of Emergency Medicine, Middlemore Hospital, Auckland, 1640 New Zealand

National Poisons Centre, Dunedin, 9054 New Zealand

Mark Marshall, Department of Renal Medicine, Middlemore Hospital, Counties Manukau Health, Private Bag 93311, Otahuhu, Auckland, 1640 New Zealand

Baxter Healthcare (Asia Pacific) Pte Ltd, Singapore, 189673 Singapore

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