Preprint / Version 1

Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre

Authors

  • Farzana Khan Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh
  • Md Sarker Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh
  • Long Ming PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei
  • Isa Mohamed Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia (The National University of Malaysia), Cheras, Malaysia
  • Chao Zhao College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China
  • Bassem Sheikh Faculty of Medicine, Taibah University, Almadinah Almunawwarah, Saudi Arabia
  • Hiew Tsong Alpro Pharmacy and Powerlife, Port Dickson, Malaysia
  • Mohammad Rashid Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh

Keywords:

Gymnema sylvestre, phytomedicine, antidiabetic, herbal medicine, traditional medicine, complementary and alternative medicine, immunomodulating, lipid lowering

Abstract

Gymnema sylvestre is a plant included in Apocynaceae family and is located in many regions of Asia, Africa and Australia. This plant is widely used as a traditional therapy for different purposes. Even now it is being used as a dietary supplement due to its numerous therapeutic uses. It is known to have blood glucose lowering potential and, thus, is widely used in traditional and Ayurvedic systems of medicine. It renders glucose lowering activity due to the presence of phytochemicals, such as gurmarin, gymnemic acid as well as gymnemasaponins. Gymnema sylvestre is also known to have anti-oxidant, antibiotic, anti-inflammatory, antiviral, gastro and hepatoprotective, anticancer and lipid-lowering activities. This review discusses in details on different pharmacological and clinical potentials of Gymnema sylvestre and its chemical constituents associated with its therapeutic potentials. Keywords: Gymnema sylvestre, phytomedicine, antidiabetic, herbal medicine, traditional medicine, complementary and alternative medicine, immunomodulating, lipid lowering

Author Biographies

Farzana Khan, Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh

Pharmacology and Toxicology Research Division, Health Med Science Research Ltd., Dhaka, Bangladesh

Md Sarker, Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh

Pharmacology and Toxicology Research Division, Health Med Science Research Ltd., Dhaka, Bangladesh

Long Ming, PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei

Division of Pharmacy, School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia

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