Roukiah Khalil
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; [email protected] (R.D.); [email protected] (R.K.); [email protected] (R.G.)
Shyam Mohapatra
Center for Research and Education in Nanobioengineering, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; [email protected]
Subhra Mohapatra
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; [email protected] (R.D.); [email protected] (R.K.); [email protected] (R.G.)
Keywords:
cancer, mechanism of action, Withania Somnifera, Withaferin A
Abstract
Ashwagandha (Withania Somnifera, WS), belonging to the family Solanaceae, is an Ayurvedic herb known worldwide for its numerous beneficial health activities since ancient times. This medicinal plant provides benefits against many human illnesses such as epilepsy, depression, arthritis, diabetes, and palliative effects such as analgesic, rejuvenating, regenerating, and growth-promoting effects. Several clinical trials of the different parts of the herb have demonstrated safety in patients suffering from these diseases. In the last two decades, an active component of Withaferin A (WFA) has shown tremendous cytotoxic activity suggesting its potential as an anti-carcinogenic agent in treatment of several cancers. In spite of enormous progress, a thorough elaboration of the proposed mechanism and mode of action is absent. Herein, we provide a comprehensive review of the properties of WS extracts (WSE) containing complex mixtures of diverse components including WFA, which have shown inhibitory properties against many cancers, (breast, colon, prostate, colon, ovarian, lung, brain), along with their mechanism of actions and pathways involved.
Keywords: cancer, mechanism of action, Withania Somnifera, Withaferin A
Center for Research and Education in Nanobioengineering, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; [email protected]
Roukiah Khalil, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; [email protected] (R.D.); [email protected] (R.K.); [email protected] (R.G.)
Center for Research and Education in Nanobioengineering, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; [email protected]
Center for Research and Education in Nanobioengineering, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; [email protected]
Shyam Mohapatra, Center for Research and Education in Nanobioengineering, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; [email protected]
James A Haley VA Hospital, Tampa, FL 33612, USA
Subhra Mohapatra, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; [email protected] (R.D.); [email protected] (R.K.); [email protected] (R.G.)
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