Preprint / Version 1

Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study

Authors

  • Mahendra Kapoor aTaiyo Kagaku Co. Ltd., Nutrition Division, 1-3 Takaramachi, Yokkaichi, Mie, 510-0844, Japan
  • Koji Suzuki bDepartment of Molecular Pathobiology, Mie University, 2-174 Edobashi, Tsu City, Mie, 514 8507, Japan
  • Timm Derek dTaiyo International Inc., Minneapolis, Minnesota, 55416, USA
  • Makoto Ozeki aTaiyo Kagaku Co. Ltd., Nutrition Division, 1-3 Takaramachi, Yokkaichi, Mie, 510-0844, Japan
  • Tsutomu Okubo aTaiyo Kagaku Co. Ltd., Nutrition Division, 1-3 Takaramachi, Yokkaichi, Mie, 510-0844, Japan

Keywords:

Amla (Emblica Officinalis Gaertn), Clinical trial, Vascular functions, Hematology, Lipid profile

Abstract

The preventive efficacies and safety of Emblica Officinalis Gatertn (Amla), a most important and extensively studied plant in the traditional Indian Ayurvedic system of medicine, are presented. Eligible healthy adult subjects (n = 15) were randomized to receive either amla or placebo (500 mg per day) during an 18-week study. The efficacy parameters evaluated were the vascular function, blood hematology, oxidative and inflammatory biomarkers, glucose and lipid profiles, urinalysis, and liver hepatotoxicity. The amla intake showed significant improvements in the primary efficacy parameter of blood fluidity. There were also improvements in the secondary endpoints including lowering of von Willebrand factor (vWF), reduced 8-hydroxy-2′-deoxyguanosine (8-OHdG) as well as thrombin (TM) biomarkers of oxidative stress along with a significant improvement in HDL-cholesterol and lowering the LDL-cholesterol levels. No substantial changes were observed in liver hepatotoxicity, urinalysis, and hematology after consumption of amla compared to baseline or placebo. In addition, no adverse events, changes safety parameters or tolerance issues were observed after consumption of amla. In conclusion, amla supplementation showed acceptable palatability, improved endothelial functions and reduced oxidative stress. Keywords: Amla (Emblica Officinalis Gaertn), Clinical trial, Vascular functions, Hematology, Lipid profile

Author Biography

Koji Suzuki, bDepartment of Molecular Pathobiology, Mie University, 2-174 Edobashi, Tsu City, Mie, 514 8507, Japan

cSuzuka University of Medical Sciences, Suzuka City, Mie, 510-0221, Japan