Volatile Compositions and Antifungal Activities of Native American Medicinal Plants: Focus on the Asteraceae

Sims Lawson; Layla Sharp; Chelsea Powers; Robert McFeeters; Prabodh Satyal; William Setzer

Authors

Sims Lawson Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected] (S.K.L.); [email protected] (L.G.S.); [email protected] (C.N.P.); [email protected] (R.L.M.)
Layla Sharp Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected] (S.K.L.); [email protected] (L.G.S.); [email protected] (C.N.P.); [email protected] (R.L.M.)
Chelsea Powers Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected] (S.K.L.); [email protected] (L.G.S.); [email protected] (C.N.P.); [email protected] (R.L.M.)
Robert McFeeters Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected] (S.K.L.); [email protected] (L.G.S.); [email protected] (C.N.P.); [email protected] (R.L.M.)
Prabodh Satyal Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA; [email protected]
William Setzer Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected] (S.K.L.); [email protected] (L.G.S.); [email protected] (C.N.P.); [email protected] (R.L.M.)

Keywords:

ethnopharmacology, essential oil, chemical composition, Cryptococcus neoformans, cyclocolorenone

Abstract

In the past, Native Americans of North America had an abundant traditional herbal legacy for treating illnesses, disorders, and wounds. Unfortunately, much of the ethnopharmacological knowledge of North American Indians has been lost due to population destruction and displacement from their native lands by European-based settlers. However, there are some sources of Native American ethnobotany remaining. In this work, we have consulted the ethnobotanical literature for members of the Asteraceae used in Cherokee and other Native American traditional medicines that are native to the southeastern United States. The aerial parts of Eupatorium serotinum, Eurybia macrophylla, Eutrochium purpureum, Polymnia canadensis, Rudbeckia laciniata, Silphium integrifolium, Smallanthus uvedalia, Solidago altissima, and Xanthium strumarium were collected from wild-growing plants in north Alabama. The plants were hydrodistilled to obtain the essential oils and the chemical compositions of the essential oils were determined by gas chromatography–mass spectrometry. The essential oils were tested for in-vitro antifungal activity against Aspergillus niger, Candida albicans, and Cryptococcus neoformans. The essential oil of E. serotinum showed noteworthy activity against C. neoformans with a minimum inhibitory concentration (MIC) value of 78 μg/mL, which can be attributed to the high concentration of cyclocolorenone in the essential oil. Keywords: ethnopharmacology, essential oil, chemical composition, Cryptococcus neoformans, cyclocolorenone

Author Biography

William Setzer, Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected] (S.K.L.); [email protected] (L.G.S.); [email protected] (C.N.P.); [email protected] (R.L.M.)

Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA; [email protected]

Volatile Compositions and Antifungal Activities of Native American Medicinal Plants: Focus on the Asteraceae

Authors

Keywords:

Abstract

Author Biography

William Setzer, Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected] (S.K.L.); [email protected] (L.G.S.); [email protected] (C.N.P.); [email protected] (R.L.M.)

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