Gut microbiota: One of the new frontiers for elucidating fundamentals of Vipaka in Ayurveda
Authors
Anagha Ranade
Research Officer (Ayu), Department of Pharmacology, Regional Ayurved Institute for Fundamental Research, Pune, Maharashtra, India
Amey Shirolkar
Department of Biochemistry, National Centre for Cell Sciences, Pune, Maharashtra, India
Sharad Pawar
Research Officer (Pharmacology), Department of Pharmacology, Regional Ayurved Institute for Fundamental Research, Pune, Maharashtra, India
Keywords:
Gut microbiota, pharmacokinetics, Vipaka
Abstract
With the increasing resurgence of Ayurvedic medicine in recent years, a lot of focus is laid on pharmacokinetics of herbs in arresting disease pathology. Ayurveda has enlisted some fundamentals in relation to drug pharmacokinetics, namely Rasa (perception), Virya (potency), Vipaka (postdigestive effect), Guna (properties), and Prabhava (special effect). In recent years, research has emphasized the role of gut microbiota in human health and metabolic processes. A thorough review was done to understand the role of microbiota in drug metabolism if any. The holistic mechanism of gut microbiota coincides to some extent, with the doctrines of Ayurveda in the context of pharmacodynamics and pharmacokinetics. This discussion is a thought put forth with an aim to elucidate the concept of Vipaka vis-a-vis gut microbiota functions.
Keywords: Gut microbiota, pharmacokinetics, Vipaka
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