Lynch syndrome (hereditary non-polyposis colorectal cancer) is an autosomal dominant condition and it is caused by germline mutations in the DNA mismatch repair genes. The present case report was conducted to evaluate the efficacy of Madhuyasti (Glycyrrhiza glabra) Ksheerpaka kalpa in Lynch syndrome. A 28-year-old male was diagnosed with Lynch syndrome in 2016. The patient was operated three times followed by chemotherapy. In 2019, he was diagnosed with adenocarcinoma and advised for surgery. But despite getting surgery patient prefer to take Ayurvedic consultation considering his miserable condition after previous surgeries. It is decided to give the kalpa method of therapy prescribed in Ayurveda for rejuvenation and overall improvement of health. After the 15 days of treatment with Madhuyasti (Glycyrrhiza glabra) Ksheerpaka Kalpa chikitsa, the patient showed significant improvement in quality of life (P < 0.001 for SPF) and CT abdomen showed a reduction in circumferential thickening from 2.8 to 1.5 cm (~50% improvement) with no worsening complications. Although the pathogenesis cannot be revert back to the normalcy as the patient already had resection of the total colon, it can be concluded that with the help of Ayurveda, the appearance of complications can be delayed and the quality of life can be improved in such patients. It is further suggested that better result may obtained if the Ayurvedic therapy starts at earlier stage.
Keywords: Kalpa chikitsa, Lynch syndrome, Madhuyasti Ksheerpaka
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