Preprint / Version 1

Recent Advances in the Discovery of Plant-Derived Antimicrobial Natural Products to Combat Antimicrobial Resistant Pathogens: Insights from 2018–2022

Authors

  • Sunmin Woo aCenter for the Study of Human Health, Emory University, USA
  • Lewis Marquez bMolecular and Systems Pharmacology Program, Laney Graduate School, Emory University, USA
  • William Crandall bMolecular and Systems Pharmacology Program, Laney Graduate School, Emory University, USA
  • Caitlin Risener bMolecular and Systems Pharmacology Program, Laney Graduate School, Emory University, USA
  • Cassandra Quave aCenter for the Study of Human Health, Emory University, USA

Keywords:

Natural products, antimicrobial, antibacterial, antivirulence, antibiofilm, antimicrobial resistance

Abstract

Antimicrobial resistance (AMR) poses a significant global health threat. Thousands of years before antibiotics were first discovered, infections were treated with plants, chosen from traditional medicine practices. Out of Earth’s 374,000 plant species, approximately 9% have been used medicinally. As antimicrobial resistance grows, and conventional antibiotics’ effectiveness wanes, the demand for innovative drug scaffolds and new targets to combat multidrug-resistant bacteria rises. This review illuminates discoveries of antimicrobial natural products from plants made between 2018 and 2022. It highlights traditional medicinal plant uses showing antibacterial, antivirulence, and antibiofilm activity in lab studies. Additionally, it discusses the development of novel derivatives from well-studied parent natural products, as these have often served as scaffolds for anti-infective agents. Keywords: Natural products, antimicrobial, antibacterial, antivirulence, antibiofilm, antimicrobial resistance

Author Biography

Cassandra Quave, aCenter for the Study of Human Health, Emory University, USA

cDepartment of Dermatology, Emory University School of Medicine, USA

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