Effect of a novel herbal vaginal suppository containing myrtle and oak gall in the treatment of vaginitis: a randomized clinical trial
Authors
Sayyede Askari
Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Bahia Jahromi
Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Amirreza Dehghanian
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Afsoon Zarei
Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Mojgan Tansaz
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Parmis Badr
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Amir Azadi
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Abdolali Mohagheghzadeh
Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Keywords:
Myrtle, Oak gall, Traditional Persian medicine, Suppository
Abstract
Uncomplicated infections such as candidiasis, bacterial vaginosis (BV), or trichomoniasis are easy to diagnose and treat. However, about 8% of patients will have a more complicated course with failure to respond to treatment or rapid recurrence of symptoms. There are many suggestions in Traditional Persian Medicine like myrtle (Myrtus communis L.) and oak gall (Quercus infectoria G.Olivier) for treatment of vaginitis.
Objectives
A clinical trial was designed to assess the efficacy of a novel herbal suppository, containing myrtle and oak gall (MOGS) in treatment of vaginitis.
Methods
In a parallel randomized clinical trial, 120 women with vaginitis were randomly assigned to MOGS, metronidazole, or placebo. Formulation was simulated from traditional Persian manuscripts and MGOS was prepared after pharmaceutical optimization processing as well as quantification of gallic acid by HPLC. The study was double-blind for MOGS and placebo and single-blind for metronidazole group.
Results
MOGS effectively improved vaginal discharge (p = 0.024 for BV and 0.018 for trichomoniasis) and pH (compared to placebo (p = 0.013) and metronidazole (p = 0.001)). Both MOGS and metronidazole could reverse whiff test. Metronidazole was the best medication for making Nugent score negative (p = 0.005) as well as the best therapy according to laboratory findings to treat BV in comparison with placebo (p = 0.021). While for trichomoniasis, MOGS could improve the disease more successfully (p = 0.001). Both MOGS and metronidazole treated mixed vaginitis (p = 0.002).
Conclusion
MOGS would be a chance for developing new treatment for trichomoniasis.
Graphical abstract
Keywords: Myrtle, Oak gall, Traditional Persian medicine, Suppository
Author Biographies
Bahia Jahromi, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Afsoon Zarei, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Parmis Badr, Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Phytopharmaceutical Technology and Traditional Medicine Incubator, Shiraz University of Medical Sciences, Shiraz, Iran
Amir Azadi, Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Abdolali Mohagheghzadeh, Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
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