Neuroprotective potential of Myrica esulenta in Haloperidol induced Parkinson’s disease
Authors
Atul Kabra
aIKG Punjab Technical University, Kapurthala, Punjab, India
Uttam Baghel
cDepartment of Pharmacy, University of Kota, Kota, 325003, Rajasthan, India
Christophe Hano
dLaboratoire de Biologie des Ligneux et des Grandes Cultures, INRA USC1328, Orleans University, 45067 CEDEX 2, Orléans, France
Natalia Martins
fFaculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319, Porto, Portugal
Mohammad Khalid
hDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
Rohit Sharma
iDepartment of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India
Myrica esculenta is a notable therapeutic plant widely utilized in Indian system of medicine. Ayurvedic literature reported fruit and bark of this plant is used in gulma, jvara, arsa, grahani, pandu roga, hrillasa, mukha roga, kasa, svasa, agnimandhya, aruchi, meha, and kantharoga.
Objective
The present study aimed to investigate the neuroprotective potential of “Himalayan Bayberry” (Myrica esculenta Buch.-Ham. ex D. Don) leaves methanol extract in Parkinson’s disease induced by haloperidol.
Materials and methods
The present investigation was completed in wistar rats, in which Parkinson’s disease (PD) was induced with haloperidol 1 mg/kg, intraperitoneally. The rats were randomly divided into six gatherings and the test animals received the methanolic extract of M. esculenta (MEME) at a dose of 50, 100 and 200 mg/kg, orally for one week. Various behavioural, biochemical and histopathological parameters were estimated in haloperidol exposed rats.
Results
MEME demonstrated significant and dose-dependent increment in behavioural activity and improved muscle coordination. The significant diminution in malonaldehyde level while improved the level of antioxidant enzymes like catalase, superoxide dismutase and reduced glutathione in extract treated group were observed as compared to the control group. Histopathological changes revealed MEME significantly reduced haloperidol-induced damage in the substantia nigra and there was very little neuronal atrophy.
Conclusion
The outcomes showed the defensive role of M. esculenta against PD. The mechanism of protection may be due to an escalation of cellular antioxidants.
Keywords: Dopamine, Methanolic extract, Catalepsy score, Neuroprotection
Author Biographies
Atul Kabra, aIKG Punjab Technical University, Kapurthala, Punjab, India
bSchool of Pharmacy, Raffles University, Neemrana, 301705, Alwar, Rajasthan, India
Christophe Hano, dLaboratoire de Biologie des Ligneux et des Grandes Cultures, INRA USC1328, Orleans University, 45067 CEDEX 2, Orléans, France
eBioactifs et Cosmetiques, CNRS GDR 3711 Orleans, 45067 CEDEX 2, Orléans, France
Natalia Martins, fFaculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319, Porto, Portugal
gInstitute for Research and Innovation in Heath (i3S), University of Porto, Rua Alfredo Allen, 4200-135, Porto, Portugal
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