Preprint / Version 1

Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases

Authors

  • Simona Bungau Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania; [email protected] (D.M.T.); [email protected] (A.L.P.); [email protected] (B.P.)
  • Cosmin Vesa Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania; [email protected]
  • Areha Abid Department of Food Science, Faculty of Agricultural and Food Sciences, University of Debrecen, 4032 Debrecen, Hungary; [email protected]
  • Tapan Behl Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India; [email protected]
  • Delia Tit Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania; [email protected] (D.M.T.); [email protected] (A.L.P.); [email protected] (B.P.)
  • Anamaria Purza Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania; [email protected] (D.M.T.); [email protected] (A.L.P.); [email protected] (B.P.)
  • Bianca Pasca Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania; [email protected] (D.M.T.); [email protected] (A.L.P.); [email protected] (B.P.)
  • Laura Todan Doctoral School of Biomedical Sciences, University of Oradea, 410073 Oradea, Romania; [email protected]
  • Laura Endres Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania

Keywords:

Withania somnifera, withaferin A, dermatology, dermatological disorders, melanoma, Ayurvedic medicine

Abstract

Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies. Keywords: Withania somnifera, withaferin A, dermatology, dermatological disorders, melanoma, Ayurvedic medicine

Author Biographies

Simona Bungau, Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania; [email protected] (D.M.T.); [email protected] (A.L.P.); [email protected] (B.P.)

Doctoral School of Biomedical Sciences, University of Oradea, 410073 Oradea, Romania; [email protected]

Delia Tit, Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania; [email protected] (D.M.T.); [email protected] (A.L.P.); [email protected] (B.P.)

Doctoral School of Biomedical Sciences, University of Oradea, 410073 Oradea, Romania; [email protected]

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