Preprint / Version 1

Evidence-based traditional Siddha formulations for prophylaxis and management of respiratory symptoms in COVID-19 pandemic-a review

Authors

  • P Prakash aDepartment of Biotechnology, School of Bio and Chemical of Engineering, Sathyabama Institute of Science and Technology, Chennai, 600 119, Tamilnadu, India
  • R Meena bSiddha Central Research Institute, (Central Council for Research in Siddha, Ministry of AYUSH, Government of India), Arumbakkam, Chennai, 600106, India
  • L Abraham cCentre for Ocean Research, Sathyabama Institute of Science and Technology, Chennai, 600 119, Tamilnadu, India
  • Swetha Sunkar dCenter for Molecular Data Science and Systems Biology, Department of Bioinformatics, Sathyabama Institute of Science and Technology, Chennai, 600 119, Tamilnadu, India
  • K Govindaraju cCentre for Ocean Research, Sathyabama Institute of Science and Technology, Chennai, 600 119, Tamilnadu, India
  • Durgasruthi Pully eFaculty of Science, KU Leuven, Leuven-3000, Belgium
  • Antony Samrot fSchool of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP2, Bandar Saujana Putra, 42610, Jenjarom, Selangor, Malaysia

Keywords:

COVID - 19, SARS-CoV-2, Antiviral property, Siddha, Immunomodulatory drugs, Pandemic

Abstract

The recent outbreak of COVID-19 is attributed to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This viral disease is rapidly spreading across the globe, including India. The mainstay in managing the disease is supportive care, nutrition, and preventing further progression in the absence of proven antiviral drugs. Currently two vaccines Covishield and Covaxin are administered in India. Long-term plans of developing most reliable mRNA-based vaccines are also underway for the future method of prophylaxis. The Siddha system of medicine's holistic approach emphasizes lifestyle modification, prophylactic interventions, and dietary management to boost the host immunity and treatment with herbal medicines and higher-order medicines as the case may be. In this review, a brief outline of the disease COVID-19, Coronavirus, evidence-based traditional Siddha interventions for respiratory ailments and immune boosters highlighting the relevant published research on individual herbs are dealt, which pave way for further research on drug repurposing for COVID-19. Historical evidence on the prevention and treatment of infections especially antivirals in Siddha classics is studied. Keywords: COVID - 19, SARS-CoV-2, Antiviral property, Siddha, Immunomodulatory drugs, Pandemic