Preprint / Version 1

Anti-urolithiatic activity of Bryophyllum pinnatum Lam. hydroalcoholic extract in sodium oxalate-induced urolithiasis in rats

Authors

  • RB Pandhare aAssociate Professor and Head Department of Pharmacology, MES's College of Pharmacy, Sonai, Newasa, Ahmednagar, MH, India
  • RR Shende bStudent, MES's College of Pharmacy, Sonai, Newasa, Ahmednagar, MH, India
  • MS Avhad bStudent, MES's College of Pharmacy, Sonai, Newasa, Ahmednagar, MH, India
  • VK Deshmukh cProfessor and Principal, MES's College of Pharmacy, Sonai, Newasa, Ahmednagar, MH, India
  • PB Mohite dAssociate Professor, MES's College of Pharmacy, Sonai, Newasa, Ahmednagar, MH, India
  • B Sangameswaran eProfessor and Principal, SSM College of Pharmacy, Chinniampalayam, Erode, Tamil Nadu, India
  • RB Daude fDepartment of Pharmacy, Government Polytechnic Jalgaon, NH-06, Jilha Peth, Jalgaon, MH, India

Keywords:

Bryophyllum pinnatum Lam., Cystone, Sodium oxalate, Urolithiasis

Abstract

Background and Aim Despite advances in modern medicine, the development and growth of calculi continues to be a source of concern for mankind, as there is no effective treatment for kidney stones. In the present study we investigated antiurolithiatic activity of Bryophyllum pinnatum Lam against sodium oxalate (NaOx) induced urolithiasis in rats. Experimental procedure In rats with renal calculi caused by sodium oxalate (NaOx, 70 mg/kg, i.p.); the antiurolithiatic action of Bryophyllum pinnatum hydroalcoholic extract (BPHE) was studied. BPHE was given every day orally at doses of 50, 200 mg/kg for 14 days to rats to examine activity against sodium oxalate (NaOx) mediated urolithiasis, with Cystone (500 mg/kg, p.o.) as a reference standard. The effect of the extract on urine oxalate, creatinine and phosphate retention and excretion in the kidney, as well as serum and biochemical analysis of kidney homogenate and histopathological examinations were studied. Results and conclusion Oral administration of BPHE at doses of 50,100, and 200 mg/kg to rats with sodium oxalate-mediated renal calculi showed dose-dependent substantial (P<0.05) antiurolithiatic potential, with notable reversal of NaOx-induced ion excretion and urinary CaOx concentration. These findings justify the traditional use of Bryophyllum pinnatum hydroalcoholic extract (BPHE) in the treatment of renal calculi. Keywords: Bryophyllum pinnatum Lam., Cystone, Sodium oxalate, Urolithiasis

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