Preprint / Version 1

Brief survey on phytochemicals to prevent COVID-19

Authors

  • Sanjoy Pal aKultikari Kshirodamoyee High School (H.S), Ghatal, Paschim Medinipur, West Bengal, India
  • Sk Saadi gDepartment of Biological Sciences, Aliah University, IIA/27, New Town, Kolkata, 700160, West Bengal, India
  • Sk Islam fDepartment of Plant Pathology, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, 741235, West Bengal, India
  • Pralay Sharma eNational Institute of Homoeopathy, Kolkata, India
  • Manjeet Singh eNational Institute of Homoeopathy, Kolkata, India
  • Sana Parveen eNational Institute of Homoeopathy, Kolkata, India
  • Sounik Manna dDepartment of Microbiology, Midnapore College (Autonomous), Paschim Medinipur, West Bengal, India
  • Kishalay Paria cDepartment of Zoology, Vidyasagar University, Midnapore, West Bengal, India
  • Trinath Chowdhury bCentral Research Facility, Indian Institute of Technology Kharagpur, Kharagpur, 721302, West Bengal, India
  • Santi Mandal bCentral Research Facility, Indian Institute of Technology Kharagpur, Kharagpur, 721302, West Bengal, India

Keywords:

Phytochemical, Molecular docking, COVID-19, Traditional plant

Abstract

The recent pandemic by COVID-19 is a global threat to human health. The disease is caused by SARS-CoV-2 and the infection rate is increased more quickly than MERS and SARS as their rapid adaptation to varied climatic conditions through rapid mutations. It becomes more severe due to the lack of proper therapeutic drugs, insufficient diagnostic tool, scarcity of appropriate drug, life supporting medical facility and mostly lack of awareness. Therefore, preventive measure is one of the important strategies to control. In this context, herbal medicinal plants received a noticeable attention to treat COVID-19 in Indian subcontinent. Here, 44 Indian traditional plants have been discussed with their novel phytochemicals that prevent the novel corona virus. The basic of SARS-CoV-2, their common way of transmission including their effect on immune and nervous system have been discussed. We have analysed their mechanism of action against COVID-19 following in-silico analysis. Their probable mechanism and therapeutic approaches behind the activity of phytochemicals to stimulate immune response as well as inhibition of viral multiplication discussed rationally. Thus, mixtures of active secondary metabolites/phytochemicals are the only choice to prevent the disease in countries where vaccination will take long time due to overcrowded population density. Keywords: Phytochemical, Molecular docking, COVID-19, Traditional plant

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