Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles
Authors
Amirtham Ranjitsingh
aDepartment of Biotechnology, Prathyusha Engineering College, Chennai 600056, India
Sandhanasamy Devanesan
bDepartment of Physics and Astronomy, College of Science, King Saud University, P.O. Box-2455, Riyadh 11451, Saudi Arabia
Mohamad AlSalhi
bDepartment of Physics and Astronomy, College of Science, King Saud University, P.O. Box-2455, Riyadh 11451, Saudi Arabia
Parameswari Paul
cDepartment of Horticulture, Molecular Genetics and Genomics Laboratory, College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, South Korea
C Padmalatha
dU G C Emeritus Fellow, MS University, India
Keywords:
Herbomineral, Kantha Rasavillai, Nanoparticles, Antiviral and anticancer
Abstract
Objective
Alternative medicine plays an important role today in searching for therapeutics for cancer and viral infection. So, a scientific validation to characterize constituents in the alternative medicines and therapeutic testing is warranted using modern instrumentation.
Methods
In the present study, an old herbomineral formulation, KanthaRasavillai [KRV], was characterized using UV–vis spectrometry, FT-IR, XRD, SEM, and TEM study. Also, In vitro and in vivo studies were done to evaluate their antiviral and anticancer activity. FT-IR and XRD studies revealed a cocktail of nanoparticles of mercury, magnetic oxide, cinnabar, and arsenic.
Results.
Based on SEM, TEM, and XRD report, KRV contains nanoparticles in the size range of 9.1 nm to 25.0 nm. FT-IR analysis exposed the presence of several anti-cancerous bioactive compounds.
Further in vitro testing against HCV virus proved KRV to inhibit HCV virus a close relative to SARS-CoV-2. MTT assay confirmed the anticancer effect of KRV against Huh-7 and MCF-7 cell lines.
Conclusion
The anticancer and antiviral properties in the ancient herbomineral drug with a cocktail of metal nanoparticles acknowledge the traditional medical practice as a pioneering approach for present-day ailments. However, the study concludes that the use of KRV depends on safety dosage and genuine preparation as described by ancient saints.
Keywords: Herbomineral, Kantha Rasavillai, Nanoparticles, Antiviral and anticancer
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