Preprint / Version 1

Pharmacognostic Study on Elsholtzia ciliata (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities

Authors

  • Qian Zhang School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 PN40 Dublin, Ireland
  • Niara Porto Laboratory of Taxonomy and Pharmacobotany, Federal University of Paraíba, João Pessoa 58051-970, Brazil; [email protected] (N.M.P.); [email protected] (M.d.F.A.)
  • Carolina Guilhon Laboratory of Pharmacology of Pain and Inflammation, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho 373, bloco F. Prédio novo ICB, Rio de Janeiro 21941-901, Brazil; [email protected] (C.C.G.); [email protected] (T.B.S.G.); [email protected] (P.D.F.)
  • Thais Giorno Laboratory of Pharmacology of Pain and Inflammation, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho 373, bloco F. Prédio novo ICB, Rio de Janeiro 21941-901, Brazil; [email protected] (C.C.G.); [email protected] (T.B.S.G.); [email protected] (P.D.F.)
  • Daniela Alviano Department of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil; [email protected]
  • Maria Agra Laboratory of Taxonomy and Pharmacobotany, Federal University of Paraíba, João Pessoa 58051-970, Brazil; [email protected] (N.M.P.); [email protected] (M.d.F.A.)
  • Patricia Fernandes Laboratory of Pharmacology of Pain and Inflammation, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho 373, bloco F. Prédio novo ICB, Rio de Janeiro 21941-901, Brazil; [email protected] (C.C.G.); [email protected] (T.B.S.G.); [email protected] (P.D.F.)
  • Fabio Boylan School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 PN40 Dublin, Ireland

Keywords:

Elsholtzia ciliata, botanical identification, chemical analysis, anti-inflammatory activity, quality control, Traditional Chinese Medicine

Abstract

Elsholtzia ciliata (Thunb.) Hyl, family Lamiaceae, is an important and popular anti-bacterial and anti-inflammatory Traditional Chinese Medicine (TCM). However, there are limited scientific studies on its anatomy and pharmacological activities. Moreover, the information of chemical constituents in relation to its non-volatile constituents are still missing. The current study aimed to evaluate the anatomic, pharmacological and phytochemical profile of Elsholtzia ciliata, providing means for the quality control of this herbal drug. The methodology designed for this study included the preparation of anatomic sections and their description, extraction, chromatography, structural elucidation of isolated compounds by NMR techniques and their quantification by HPLC using pharmacological assays (Formalin, hot plate, DPPH, antimicrobial-Gram positive, Gram Negative and fungus, and MTT assays) to confirm the activities described for this species. Results of the anatomic study are aligned with the pattern expected for plants belonging to the Lamiaceae family; Ursolic acid and Oroxylin were isolated from this plant species. The findings observed in this study indicate that Elsholtzia ciliata possess anti-inflammatory, antinociceptive, antioxidant, antimicrobial and anticancer activities. The chemical compounds isolated from its leaves and the anatomy profile of its parts provide the basis for further quality control for this plant. Keywords: Elsholtzia ciliata, botanical identification, chemical analysis, anti-inflammatory activity, quality control, Traditional Chinese Medicine

Author Biography

Qian Zhang, School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 PN40 Dublin, Ireland

Intelligent Sensing and AI Center, National University of Singapore (Chongqing) Research Institute, Chongqing 401123, China

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