COVID-19: an In Silico Analysis on Potential Therapeutic Uses of Trikadu as Immune System Boosters
Authors
Rukaiya Khasamwala
School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai India 600048
S Ranjani
School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai India 600048
S Nivetha
School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai India 600048
S Hemalatha
School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai India 600048
Keywords:
SARS-coV-2, Immune response, Trikadu, Ginger, Pepper, Long pepper, Protein–ligand interactions
Abstract
Corona virus pandemic outbreak also known as COVID-19 has created an imbalance in this world. Scientists have adopted the use of natural or alternative medicines which are consumed mostly as dietary supplements to boost the immune system as herbal remedies. India is famous for traditional medicinal formulations which includes ‘Trikadu’—a combination of three acrids, namely Zingiber officinale, Piper nigrum and Piper longum which have antioxidant properties that boost our immune system hence acting as a strong preventive measure. In this study, AutoDock 4.0 was used to study interaction between the phytocompounds of Trikadu with RNA-dependent polymerase protein and enveloped protein of the SARS-CoV-2 virus. Analysis of the results showed that coumarin, coumaperine and bisdemethoxycurcumin showed strong bonding interactions with both the proteins. We can conclude that Trikadu has the potential molecules; hence, it can be incorporated in the diet to boost the immune system as a preventive measure against the virus.
Supplementary Information
The online version contains supplementary material available at 10.1007/s12010-021-03793-5.
Keywords: SARS-coV-2, Immune response, Trikadu, Ginger, Pepper, Long pepper, Protein–ligand interactions
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