Molecular docking analysis of COX-2 with compounds from Piper longum
Authors
Dhirendra Tripathi
Department of Otorhinolaryngology, Government Medical College, Shivpuri, Shivpuri - 473638
Sravanthi Koora
Department of Pharmacology, Government Medical College Siddipet 502103, Siddipet, Telangana
K Satyanarayana
Department of Biochemistry, Government Medical College Siddipet,Siddipet 502103, Telangana India
S Basha
Department of Medical Biochemistry, School of Medicine, Haramaya university, Harar Campus,Ethiopia
Selvaraj Jayaraman
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences,Chennai-600 077, Indi
Piper longum (Indian long pepper) is known for its use as an anti inflammatory agent in Indian Ayurvedic System of medicine. Therefore, it is of interest to document the molecular docking analysis of compounds from Piper longum with COX-2 using the Autodock Vina PyRx tool. Molecular docking results show that asarinine, sesamine, fargesin, and piperlonguminine have optimal binding energy of 10, 10, -9.5 and 9.4 Kcal/mol, respectively for further consideration.
Keywords: Anti-inflammatory compunds, COX-2, Piper longum, molecular docking
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