Preprint / Version 1

Effect of “Murcchana samskara” on therapeutic efficacy of BhallatakadiGhrita

Authors

  • Sandesh Wayal aCenter for Research and Development, PRIST University, Thanjavur, Tamilnadu, 613403, India
  • Sonali Barke cDepartment of Pharmacognosy, AAEMF's Delight College of Pharmacy, Koregaon Bhima, 412216, India
  • Ganesh Nigade dPDEA's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, 412301, India
  • Pradnya Jagtap dPDEA's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, 412301, India
  • Nilambari Gurav eDepartment of Pharmacognosy, PES's Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa University, Goa, 403401, India
  • Satyendra Prasad fDepartment of Pharmaceutical Sciences, R.T.M. University, Nagpur, Maharashtra, 440033, India
  • Manish Wanjari gRegional Ayurveda Research Institute for Drug Development, Pune, Maharashtra, India
  • Muniappan Ayyanar hDepartment of Botany, A. Veeriya Vandayar Memorial Sri Pushpam College (Autonomous), Affiliated to Bharathidasan University, Poondi, Thanjavur, 613 503, Tamil Nadu, India
  • Shailendra Gurav iDepartment of Pharmacognosy, Goa College of Pharmacy, Panaji, Goa University, Goa, 403 001, India

Keywords:

Polyherbal, Ghrita, Wound breaking strength, Incision wound, Excision wound, Aayurveda

Abstract

‘Bhallatakadi Ghrita’ (BG), comprising the plant extracts of Semecarpus anacardium L., Argemone mexicana L., Cocculus hirsutus L., and Woodfordia fruticosa K. ‘Murcchana samskara’ of ghee before any ‘ghrita-paka’ preparation evidenced the maximum acceptability for topical application. The current study dealt with the effect of the ‘Murcchana’ process on the therapeutic efficacy of BG. In the first step, ‘Murcchita’ ghee was prepared as per reference texts and then developed the ‘Murcchita Bhallatakadi Ghrita’ (M-BG), which was further assessed for wound healing activity using incision and excision wound animal models. ‘Murcchanasamskara’ altered the wound healing ability of M-BG (100% wound contraction on 15th post wounding day with 13.50 ± 0.22 days complete re-epithelization time and 562.33 ± 7.37 g breaking strength). The presence of antioxidants, polyphenols, flavonoids, and fatty acids (known for their potential wound healing properties) in M-BG could accelerate the wound contraction rate (P < 0.001). The present investigation has corroborated the Ayurvedic/traditional attribute of ‘Murcchanasamskara’ to augment the medicinal properties of the BG. Keywords: Polyherbal, Ghrita, Wound breaking strength, Incision wound, Excision wound, Aayurveda Abbreviations: BG, Bhallatakadi Ghrita; M-BG, Murcchita Bhallatakadi Ghrita; WBS, Wound Breaking Strength; PI, Povidone Iodine; CPCSEA, Committee for the Purpose of Control and Supervision of Experiments on Animals; OECD, Organisation for Economic Co-operation and Development; ANOVA, Analysis of Variance; SEM, Standard Error of Mean

Author Biography

Sandesh Wayal, aCenter for Research and Development, PRIST University, Thanjavur, Tamilnadu, 613403, India

bDepartment of Pharmacognosy, JSPM's Charak College of Pharmacy & Research, Wagholi, Pune, Maharashtra, 412207, India

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