Preprint / Version 1

Bioactive secondary metabolites in Paris polyphylla Sm. and their biological activities: A review

Authors

  • Chandra Thapa aCentral Department of Botany, Tribhuvan University, Kirtipur, Nepal
  • Mukti Paudel aCentral Department of Botany, Tribhuvan University, Kirtipur, Nepal
  • Hari Bhattarai aCentral Department of Botany, Tribhuvan University, Kirtipur, Nepal
  • Krishna Pant aCentral Department of Botany, Tribhuvan University, Kirtipur, Nepal
  • Hari Devkota cGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  • Yagya Adhikari dDepartment of Disturbance Ecology, University of Bayreuth, Bayreuth, Germany
  • Bijaya Pant aCentral Department of Botany, Tribhuvan University, Kirtipur, Nepal

Keywords:

Biological activities, IC50, Paris saponin, Rhizome, Vulnerable

Abstract

Paris polyphylla Sm. is an important medicinal plant used to treat a variety of diseases through traditional medicine systems such as Ayurveda, Tibetan traditional medicines, Chinese traditional medicines, and others around the world. The IUCN red list has designated it as "vulnerable" due to a decline in wild population by over-exploitation, habitat degradation, illegal collection for trade and traditional use. This review paper aims to summarize the bioactive secondary metabolites in Paris polyphylla. Paris saponins or steroidal saponins are the main bioactive chemical constituents from this plant that account for more than 80% of the total compounds. For instance, polyphyllin D, diosgenin, paris saponins I, II, VI, VII, and H are steroidal saponins having anticancer activity comparable to synthetic anticancer medicines. Antioxidant, anticancer, anti-leishmaniasis, antibacterial, antifungal, anthelmintic, antityrosinase, and antiviral effects of extracts and pure compounds were also demonstrated in vivo and in vitro. In conclusion, this review summarizes the bioactive components from the P. polyphylla which will be useful to researchers and scientists, and for the development of potential drugs. Keywords: Biological activities, IC50, Paris saponin, Rhizome, Vulnerable

Author Biography

Chandra Thapa, aCentral Department of Botany, Tribhuvan University, Kirtipur, Nepal

bButwal Multiple Campus, Tribhuvan University, Butwal, Nepal

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