Assessment of in vitro anti-skin aging activities of Phyllanthus indofischeri Bennet extracts for dermatological and aesthetic applications
Authors
Korawinwich Boonpisuttinant
Innovative Natural Products from Thai Wisdom Research Unit, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathumthani, 12130 Thailand
Kitrawi Samothai
Innovative Natural Products from Thai Wisdom Research Unit, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathumthani, 12130 Thailand
Wirinda Chompoo
Innovative Natural Products from Thai Wisdom Research Unit, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathumthani, 12130 Thailand
Jinapa Sangsee
Innovative Natural Products from Thai Wisdom Research Unit, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathumthani, 12130 Thailand
Rattiya Kansawang
Innovative Natural Products from Thai Wisdom Research Unit, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathumthani, 12130 Thailand
Sarinporn Udompong
Innovative Natural Products from Thai Wisdom Research Unit, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathumthani, 12130 Thailand
Romchat Chutoprapat
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330 Thailand
Warintorn Ruksiriwanich
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200 Thailand
Thanachai Taka
iCell Research Institute Laboratory Unit, Bangkok, 10230 Thailand
Ratakorn Srisuttee
Faculty of Medicine, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, 10520 Thailand
Keywords:
Subject terms: Chemical biology, Molecular biology, Plant sciences, Molecular medicine
Abstract
Giant Indian Gooseberry (GIG) or Phyllanthus indofischeri Bennet are commercially cultivated and commonly used herbs in Traditional medicine, especially in Thailand. The aim of this study was to assess the potential of the GIG extracts in anti-aging activities to be a dermatological application. The juice, meat residues, and seeds of GIG collected from Sra Kaeo Province, Thailand, were extracted by the Boiling method (B) and the Maceration process (M) by using 95% ethanol as a solvent. The GIG extracts gave the total phenolic, total flavonoid contents and quercetin contents, as well as exhibited anti-oxidative activities. The GIG-R-B extract inhibited tyrosinase activity and had the highest anti-melanogenesis activity on B16F10 cells at 31.63 ± 0.70%. The GIG-S-B, GIG-S-M, and GIG-R-M extracts demonstrated the highest collagen biosynthesis, which was comparable to vitamin C (p < 0.05), whereas the GIG-R-B extracts gave the highest stimulation of anti-aging genes (SIRT1 and FOXO1). All extracts at the concentration of 0.1 mg/mL showed no cytotoxicity on human skin fibroblasts. Therefore, the GIG-S-B extract was discovered to be a promising natural anti-aging agent for dermatological health and aesthetic applications that can be further developed in cosmetic, functional food and food supplement industries.
Subject terms: Chemical biology, Molecular biology, Plant sciences, Molecular medicine
Author Biography
Warintorn Ruksiriwanich, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200 Thailand
Lanna Rice Research Center, Chiang Mai University, Chiang Mai, 50200 Thailand
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