Preprint / Version 1

Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation

Authors

  • Urooj Fatima Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India
  • Asimul Islam Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India
  • Mohd Adnan Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia
  • Rana Alsaffar Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
  • Ilyas Khan Department of Mathematics, College of Science Al-Zulfi, Majmaah University, Al-Majmaah, Saudi Arabia
  • Wafaa Elkady Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Future University in Egypt, New Cairo, Egypt
  • Sabeeha Ali Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India
  • Shahnawaz Ahmad School of Biotechnology, IFTM University, Moradabad, India
  • Sonam Roy Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India
  • Md Hassan Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India

Keywords:

pharmacological potential, tau aggregates, Bacopa monnieri, anti-cancer agents, neurodegenerative diseases

Abstract

Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in combination with other herbs, as a memory and learning enhancer, sedative, and anti-epileptic. This review aimed to highlight the health benefits of B. monnieri extracts (BME), focusing on anti-cancer and neurodegenerative diseases. We examined the clinical studies on phytochemistry and pharmacological application of BME. We further highlighted the mechanism of action of these extracts in varying types of cancer and their therapeutic implications. In addition, we investigated the underlying molecular mechanism in therapeutic interventions, toxicities, safety concerns and synergistic potential in cognition and neuroprotection. Overall, this review provides deeper insights into the therapeutic implications of Brahmi as a lead formulation for treating neurological disorders and exerting cognitive-enhancing effects. Keywords: pharmacological potential, tau aggregates, Bacopa monnieri, anti-cancer agents, neurodegenerative diseases

Downloads