Preprint / Version 1

Ayurveda and in silico Approach: A Challenging Proficient Confluence for Better Development of Effective Traditional Medicine Spotlighting Network Pharmacology

Authors

  • Rashmi Sahu Department of Balroga, Shri NPA Govt. Ayurveda College, Raipur, Chhattisgarh 492010 India
  • Prashant Gupta Department of Balroga, Shri NPA Govt. Ayurveda College, Raipur, Chhattisgarh 492010 India
  • Amit Mishra Cellular and Molecular Neurobiology Unit, Indian Institute of Technology, Jodhpur, Rajasthan 342037 India
  • Awanish Kumar Department of Biotechnology, National Institute of Technology, Raipur, Chhattisgarh 492010 India

Keywords:

Ayurveda, in silico approach, confluence, challenge, effective therapeutics

Abstract

Coalescence of traditional medicine Ayurveda and in silico technology is a rigor for supplementary development of future-ready effective traditional medicine. Ayurveda is a popular traditional medicine in South Asia, emanating worldwide for the treatment of metabolic disorders and chronic illness. Techniques of in silico biology are not much explored for the investigation of a variety of bioactive phytochemicals of Ayurvedic herbs. Drug repurposing, reverse pharmacology, and polypharmacology in Ayurveda are areas in silico explorations that are needed to understand the rich repertoire of herbs, minerals, herbo-minerals, and assorted Ayurvedic formulations. This review emphasizes exploring the concept of Ayurveda with in silico approaches and the need for Ayurinformatics studies. It also provides an overview of in silico studies done on phytoconstituents of some important Ayurvedic plants, the utility of in silico studies in Ayurvedic phytoconstituents/formulations, limitations/challenges, and prospects of in silico studies in Ayurveda. This article discusses the convergence of in silico work, especially in the least explored field of Ayurveda. The focused coalesce of these two domains could present a predictive combinatorial platform to enhance translational research magnitude. In nutshell, it could provide new insight into an Ayurvedic drug discovery involving an in silico approach that could not only alleviate the process of traditional medicine research but also enhance its effectiveness in addressing health care. Electronic Supplementary Material Supplementary material (Appendixes 1–6) is available in the online version of this article at 10.1007/s11655-022-3584-x. Keywords: Ayurveda, in silico approach, confluence, challenge, effective therapeutics

Author Biography

Prashant Gupta, Department of Balroga, Shri NPA Govt. Ayurveda College, Raipur, Chhattisgarh 492010 India

Ayurinformatics Lab, Department of Kaumarabhritya, All India Institute of Ayurveda, Sarita Vihar, New Delhi, 110076 India

Downloads