Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways
Authors
Neetu Singh
Department of Botany, Maharshi Dayanand University, Rohtak, Haryana, 124001, India
Surender Yadav
Department of Botany, Maharshi Dayanand University, Rohtak, Haryana, 124001, India
Keywords:
Anticancer, Cytotoxicity, Inflammation, Natural products, QSAR, Traditional uses
Abstract
Cancer is among the major cause of demise worldwide. Though the array of anticancer chemical medications is available but unfortunately, they are also associated with negative health effects. The invaluable therapeutic potential of spices makes them an integral part of our daily diet. Therefore, the present work focuses on the traditional uses of 46 spices and the phytochemical analysis of 31 spices. Out of them, only 29 spices are explored for their cytotoxicity against different cancer cell lines. The pre-clinical and clinical anticancer studies of spices along with their toxicity, mechanism of actions like Wnt/β-catenin, phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), JAK/STAT, mitogen-activated protein kinase (MAPK), Notch-mediated pathways and Quantitative structure-activity relationship (QSAR) studies were also focused. Curcumin was found as one of the most explored bioactive in every aspect such as in-vitro, in-vivo, clinical as well as SAR anticancer studies while some other bioactive such as 1,8-Cineole, trans-Anethole, Diosgenin, Trigonelline are either unexplored or least explored for their clinical and SAR studies. In fact, traditional medicinal uses of spices also provide solid shreds of evidence for the new leads towards the invention of novel anticancer agents. Therefore, further research can be designed for the anticancer marketed formulation from spices after having their placebo and related toxicological data.
Keywords: Anticancer, Cytotoxicity, Inflammation, Natural products, QSAR, Traditional uses
Chemical compounds studied in this article: Curcumin, Pubchem CID: 839564, Cardamonin, Pubchem CID: 557026, Eugenol, Pubchem CID: 13876103, Piperine, Pubchem CID: 553590, 6-Gingerol, Pubchem CID: 391126, Capsaicin, Pubchem CID: 1265957, Cinnamaldehyde, Pubchem CID: 637511, Linalool, Pubchem CID: 391430, Rosmarinic acid, Pubchem CID: 4445104, Thymol, Pubchem CID: 21105998
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